Table 1 shows that the PCOS group had significantly higher acne grade scores, F-G scores, average ovarian volumes, DBP, WC, waist-to-hip ratio, TT, LH, LH/FSH ratio, FAI, fasting Ins, HOMA-IR, 2-h Glu and 2-hour insulin after the glucose challenge (2-h Ins), LDL-C, TC, TG, TG/HDL-C ratio, apoB, TOS, T-AOC, GSH, OSI, TOS/GSH ratio, and plasma HMOX1 levels, but lower serum FSH, SHBG, and HDL-C concentrations than the control group (P < 0.05). The gene discussed is SHBG; the disease is acne.