HMOX1 rs2071746T/A and (GT)n repeat polymorphisms significantly affected BMI, waist-to-hip ratio, TT, FAI, acne grade score, HDL-C, GSH, and TOS/GSH ratio, but not plasma HMOX1 levels among the PCOS and/or control participants, supporting that the two variants may be involved in obesity, endocrine abnormalities, oxidative stress, and metabolic disorders. The gene discussed is HMOX1; the disease is obesity due to melanocortin 4 receptor deficiency.