AFP and hepatocellular carcinoma: High AFP levels did not correlate significantly with ORR (OR = 0.96, 95%CI=0.74-1.24, p = 0.767) but were associated with a worse DCR (OR = 0.50, 95%CI=0.29-0.84, p = 0.009) in ICIs-treated HCC patients (Figure 4A).