HCC patients treated with ICIs who exhibited an AFP response had significantly higher ORR (OR = 5.39, 95%CI=3.96-7.32, p < 0.001) and DCR (OR = 5.48, 95%CI=3.71-8.11, p < 0.001) compared to those without an AFP response (Figure 4B). The gene discussed is AFP; the disease is hepatocellular carcinoma.