1. Promote angiogenesis (decreased the hypermethylation of microRNA 200a and increase the expression of VEGF; activates the Ang2/Tie2 pathway)2. Anti-inflammation and calcification primarily (via the NO-TGFβR1-YAP/TAZ signaling pathway)3. Anti-Atherosclerosis (inhibition of ferroptosis via Keap1/Nrf2 signaling pathway)4. Protection of vascular endothelium (downregulating the MyD88/TRAF6/NF-κB pathway via upregulating miR-147a)5. anti-platelet (via AA/COX-1/TXB2 pathway). The gene discussed is TGFBR1; the disease is atherosclerosis.