1. Anti-Atherosclerosis (via inhibiting macrophage foam-cell formation −/−)2. Protection of vascular endothelium (reduce LDH, MDA, GSSG, and increase GSH)3. Anti-inflammation (decrease IL-1β、IL-6)4. Promote angiogenesis (HIF-1α/VEGF signaling pathway). This evidence concerns the gene IL1B and atherosclerosis.