1. Anti-inflammation (decrease TNF-α and IL-6 via the p38-HO-1 pathway)2. Anti-Atherosclerosis (metabolic-dependent anti-EndMT pathway and repression of TGF-β/ALK5 signaling)3. Anti-oxidant stress (reduce LDH, ROS and increase SOD by downregulating miR-204-5p). The gene discussed is TGFBR1; the disease is atherosclerosis.