MAP2K1 and atherosclerosis: 1. Anti-Atherosclerosis (induction of macrophage autophagy via Promotion of AMPK Phosphorylation)2. Protection of vascular endothelium (via p38/JNK/eNOS/NO pathway)3. Anti-inflammation (by inhibiting MAPK signaling and MEK1/2 activation; suppressing STING-mediated macrophage activation)4. Promote angiogenesis (increase the expression of VEGF)