Among these, two common targets of Diuretics and Agents acting on the renin‐angiotensin system are associated with a reduced risk of migraine: BLM (OR (95% CI) = 0.922 (0.885−0.96), PSMR = 7.17×10−5), PAM (OR (95% CI) = 0.962 (0.941−0.983), PSMR = 3.80×10−4), and SERPINC1 (OR(95% CI) = 0.891 (0.82−0.969), PSMR = 7.12×10−3). The gene discussed is SERPINC1; the disease is migraine disorder.