The results of the SMR, colocalization, and INTACT sensitivity analyses provided further validation of BLM, C12orf76, GPATCH4, PAM, SERPINC1 as contraindicated drugs’ target genes for migraine, and ALMS1, GPATCH4, NCF2, SLC12A1, ZKSCAN8P1 for migraine with aura. Here, ZKSCAN8P1 is linked to migraine with aura.