At the brain‐tissue level, we further validated hub gene associations: in migraine, SERPINC1, ZKSCAN8P1, C12orf76, and PAM were significant across brain regions; in migraine with aura, SERPINC1, ALMS1, ZKSCAN8P1, PAM, and NCF2 were significant. This evidence concerns the gene C12orf76 and migraine with aura.