The results of the SMR, colocalization, and INTACT sensitivity analyses provided further validation of BLM, C12orf76, GPATCH4, PAM, SERPINC1 as contraindicated drugs’ target genes for migraine, and ALMS1, GPATCH4, NCF2, SLC12A1, ZKSCAN8P1 for migraine with aura. The gene discussed is C12orf76; the disease is migraine with aura.