The results of the SMR, colocalization, and INTACT sensitivity analyses provided further validation of BLM, C12orf76, GPATCH4, PAM, SERPINC1 as contraindicated drugs’ target genes for migraine, and ALMS1, GPATCH4, NCF2, SLC12A1, ZKSCAN8P1 for migraine with aura. This evidence concerns the gene GPATCH4 and migraine with aura.