TB maintains its position as a global health priority, with antimicrobial resistance patterns—especially MDR-TB and XDR-TB strains—creating significant barriers to effective disease management and control.[14] This study characterizes the diagnostic potential of serum ANKRD22 and SERPING1 as biomarkers for drug-resistant TB, with implications for timely therapeutic decision-making. This evidence concerns the gene SERPING1 and tuberculosis.