IL-5 also plays a role in RA since IL-5 targeting biologic disease-modifying antirheumatic drugs used to treat asthma can trigger RA as a side effect.[46] IL-13 is another well-known actor in RA that modulates the activity of the immune cells.[48] Increased serum PMO is another well-known feature of RA. The gene discussed is IL5; the disease is asthma.