KL and colorectal cancer: For instance, in renal cell carcinoma, Klotho is known to suppress tumor proliferation and promote apoptosis, while in gastric cancer, its reduced expression is linked with enhanced tumor migration and invasion.[31–33] Similarly, in breast and colorectal cancers, Klotho influence extends to regulating critical signaling pathways such as the Wnt pathway, emphasizing its broad regulatory capabilities in cellular processes including proliferation, apoptosis, and the epithelial-mesenchymal transition.[34,35]