While previous studies have extensively documented the role of the Klotho protein as a potential tumor suppressor and modulator of insulin-like growth factor 1 receptor (IGF1R) signaling in various cancers, including T- and B-cell lymphomas.[9,10] However, in our study, we found no statistically significant evidence to support a causal effect of the Klotho protein on B-cell lymphoma. This evidence concerns the gene IGF1R and cancer.