NF1 and Cafe-au-lait spot: The clinical tapestry of NF1 is woven with characteristic manifestations such as neurofibromas, café-au-lait macules (CALMs), skinfold freckling, Lisch nodules, and an array of central nervous system tumors.[1] The roots of NF1 pathogenesis are firmly anchored in mutations within the NF1 gene, situated on chromosome 17q11.2, which encodes the vital protein neurofibromin.