Prior studies have reported that NORAD negatively regulates hsa-miR-204-5p, with elevated NORAD expression correlating with increased inflammatory markers such as TNF-α, IL-6, CRP, and ESR in RA patients.[36] However, the downstream target genes of the NORAD/miR-204-5p axis remain largely undefined. The gene discussed is ESR1; the disease is rheumatoid arthritis.