SCUBE2 and breast cancer: Not only has it been identified as a potential tumor suppressor in certain malignancies, but its aberrant expression patterns have also been correlated with tumor progression and patient prognosis in various cancer types.[37] Wu et al, through single-cell sequencing, identified that SCUBE2 facilitates bone metastasis in luminal breast cancer by altering immune-suppressive osteoblastic niches.[38] Collectively, these genes offer profound insights into the molecular intricacies of PCa, and a deeper exploration can drive innovative therapeutic strategies.