Univariate logistic regression analysis showed that IFI27, ELANE, IFITM3, and C3AR1 were risk factors while SH2D1B was a protective factor for PSC and SLE (Table S8, Supplemental Digital Content, https://links.lww.com/MD/Q501). The gene discussed is IFITM3; the disease is systemic lupus erythematosus.