The expression levels of the 5 genes in the PSC and SLE datasets are shown in Figure 6C and D. IFI27, ELANE, IFITM3, and C3AR1 showed increased expression in both the PSC and SLE samples compared with the control samples, whereas SH2D1B exhibited decreased expression. The gene discussed is SH2D1B; the disease is systemic lupus erythematosus.