IFI27 and IFITM3 were found to be associated with SLE through single-cell sequencing and RNA sequencing data analyses.[38–40] ELANE and C3AR1 were reported to be related to renal involvement in SLE patients.[41,42] Further research is needed to investigate the significance of shared hub genes to develop targeted therapies for PSC and SLE. The gene discussed is ELANE; the disease is systemic lupus erythematosus.