HOMA-IR is calculated using fasting insulin, which limits the application in the general population because fasting insulin is typically measured in diabetic patients.[42] Similarly, the TyG index only incorporates fasting glucose and triglycerides, neglecting other factors closely related to IR and MAFLD, such as central obesity and hypertension.[43] eGDR incorporates body size, HbA1c levels, and hypertension status, all routinely assessed upon admission of people with MAFLD, hence, it is particularly suitable for early diagnosis of MAFLD. The gene discussed is INS; the disease is Hypertension.