INS and hypertensive disorder: HOMA-IR is calculated using fasting insulin, which limits the application in the general population because fasting insulin is typically measured in diabetic patients.[42] Similarly, the TyG index only incorporates fasting glucose and triglycerides, neglecting other factors closely related to IR and MAFLD, such as central obesity and hypertension.[43] eGDR incorporates body size, HbA1c levels, and hypertension status, all routinely assessed upon admission of people with MAFLD, hence, it is particularly suitable for early diagnosis of MAFLD.