Dpep expression changes in the context of inflammatory diseases, indicating that they may be related to immune responses.[61,62] Currently, there is no research directly linking DPEP2 to DU, but some studies have found that DPEP2 is a central gene in colorectal adenocarcinoma that can affect the prognosis of colorectal cancer.[63] Our study found that DPEP2 is a risk factor for DU and has been validated in other GWAS data. This evidence concerns the gene DPEP2 and colorectal cancer.