CLK1 and neurodegenerative disease: It is primarily localized in the nucleus and plays a critical role in regulating phosphorylation of SR proteins and pre-mRNA splicing processes.[25] Studies have demonstrated that CLK1 phosphorylates key splicing factors such as U1-70K and SRSF1, altering their conformation and promoting the assembly of U1 small nuclear ribonucleoprotein, thereby regulating splice site recognition.[26,27] Aberrant RNA splicing is closely associated with chronic inflammation and various degenerative diseases.