AKT1 and infarction: Saponins in SJS mitigate ischemic damage at both the organ level (reduced infarction area and improved electrocardiogram parameters) and the cellular level (activation of anti-apoptotic PI3K/Akt/mTOR and MAPK/Akt survival pathways), while also stabilizing electrophysiological activity through calcium current modulation and antiarrhythmic Bcl-2/Bax rebalancing.