NFE2L2 and Parkinson disease: Irisin was revealed to have neuroprotective effects on PD by activating the ERK, P38MAPK and AMPK pathways and then upregulating Nrf2, HO-1, and Bcl-2 independently of NF-κB, reducing the release of cytokines and the NLRP3 inflammasome and Caspase-1 [87].