[43] reported that SlpA from selected C. difficile ribotypes variably downregulated the expression of tight junction–associated genes and increased TLR4 expression and pro‐inflammatory cytokine production in HT‐29 cells, a human colorectal adenocarcinoma cell line widely used as an in vitro model of intestinal epithelial cells [43]. The gene discussed is TLR4; the disease is colorectal adenocarcinoma.