GPX4 and concussion: Furthermore, this pathway is closely linked to autophagy, a process intricately associated with neuronal survival and death (Zhu et al. 2016; Hwang et al. 2017).Building upon these insights, our study extends current knowledge by directly demonstrating the association between PI3K/AKT/mTOR signaling and GPX4 regulation in mTBI, and further emphasizes the role of mTOR as a central regulatory node within the ferroptosis signaling network.