All of these results are in agreement with, and extend, previous observations on cellular conjugates, for example, homotypic and heterotypic circulating-tumour-cell clusters with different properties21, interacting CD4+ T cell–APC clusters characterized by PIC-seq22,23 and the importance of spatial positioning of CD4+–CD8+ T cell–DC triads56,57. The gene discussed is CD8A; the disease is neoplasm.