CD8A and melanoma: Cell–cell communication analysis revealed that specifically the T-cell-interacting, immune-response-associated melanoma subpopulation showed higher expression of ligands mediating T cell attraction (for example, CCL5–CCR5, CXCL9/10–CXCR3), immune synapse formation (for example, HLA-CD8 and ICAM1–ITGAL) and immune modulation (for example, PD-L1–PD-1) (Extended Data Fig. 5j).