CTNNB1 and hepatocellular carcinoma: We found that the WNT-driven gene expression signature in the Ctnnb1ex3/WT;R26LSL-MYC proliferative lesions strongly correlated with the CTNNB1;MYC-mutated HCC and Hoshida subtypes S2 (characterized by proliferation and MYC activation) and S3 (associated with hepatocyte differentiation)20, whereas the single clones more closely resembled CTNNB1-mutated HCC with normal MYC copy number (Extended Data Fig. 2d–g).