To investigate how sporadically mutated Ctnnb1ex3/WT;R26LSL-MYC hepatocytes progress to tumours, we examined Ctnnb1ex3/WT;R26LSL-MYC mosaic livers 30 and 60 days after treatment with a low viral titre of AAV8.TBG.Cre (Fig. 1a). Here, MYC is linked to neoplasm.