The median ages of the carriers of the MLH1, MSH2, MSH6 and PMS2 genes were 49.5, 51, 52, and 56 years, respectively, and the patients harboring PMS2 germline P/LP variants were significantly older than the patients harboring MLH1 germline P/LP variants (Fig. 2C), indicating that the trend of the age distribution in the Non-CNS LS-related tumor group was consistent with previous reports5. The gene discussed is PMS2; the disease is neoplasm.