The results revealed that the age of patients harboring PMS2 germline P/LP variants in the Non-CNS LS-related tumor group was significantly greater than that of patients harboring MLH1 germline P/LP variants (p = 0.0499), but beyond that, there was no significant difference in age between the 4 P/LP variant genes in the same group. This evidence concerns the gene MLH1 and neoplasm.