MSH6 and neoplasm: In brief, we found that tumor samples in the three groups exhibited heterogeneity in the distribution of germline pathogenic genes (Fig. 2A, B), and there were significant differences in age among the three groups, with the age of the CNS LS-related tumor group being lower than that of the other two groups, especially in patients harboring MSH6 and PMS2 germline P/LP variants (Table 1 and Fig. 2C).