The characteristics of the non-CNS LS-related tumor group in our study were similar to those reported in previous studies, with incidence rates of EC (5.68%) and CRC (1.96%)34–36, a mean age of 52.8 years9, a proportion of MLH1 and MSH2 genes with germline variants being the highest5,34, a median TMB being high (51.47, from 0.71 to 412.06), and a ratio of MSI-H being 70.1%8. Here, MSH2 is linked to neoplasm.