MAPT and Alzheimer disease: Inactivation of AD-derived tau seeds was titratable in terms of sodium hypochlorite concentrations and incubation times (Figs. 6D and S6C), with a 5 min incubation in 5% NaOCl, reducing the tau-seeding ability of the AD-derived material by 97% without affecting the viability of the cells (Fig. S6D).