Finally, verification of qRT-PCRresults revealed that CTSB (P=0.001) and HNRNPL (P=0.002) were upregulated, KRAS(P=0.003) and MAP1LC3A (P=0.004) were downregulated in ICAS group, compared withhealthy controls. The gene discussed is MAP1LC3A; the disease is familial isolated congenital asplenia.