Cyclic adenosinemonophosphate (cAMP) responsive element binding protein 1(CREB1) is known as atranscription factor which bind to promoter cis-regulatory elements, ubiquitouslyexpressing in many tissues (Li et al., 2022).CREB can promote the transcription of GPX4 in the absence of EP300, suppressingferroptosis in lung adenocarcinoma (Wang et al.,2021 b ). Here, EP300 is linked to lung adenocarcinoma.