MYC and neoplasm: The role of c-Myc in cell proliferation is linked to its ability to promote progression from G1 and into the S phase of the cell cycle.48 It has been reported that c-Myc depletion inhibits proliferation of human tumor cells at various cell cycle stages.49 The differences in cell cycle responses to c-Myc downregulation observed in our results further highlight the heterogeneity of c-Myc as a regulator of SCC cell proliferation.