To verify whether monocyte- and macrophage-CM modulate the tumor plasticity of SCC cells, we analyzed the expression of genes associated with epithelial-mesenchymal transition (EPCAM, SOX2), stemness (NANOG, MYC, EZH2), and neuroendocrine differentiation (CHGA, AURKA, MYCN). This evidence concerns the gene SOX2 and neoplasm.