The levels of the human scavenger receptor CD163 are significantly elevated in M2-like macrophages.29 The presence of M1 and M2 macrophages on peritumoral inflammation areas, but not within the tumor stroma, was positively correlated with higher grades of oral tongue SCC, suggesting that the spatial distribution of TAMs within tumors impacts patient prognosis.30 The presence of both M1 and M2 macrophages in the TME creates a dynamic immune environment, often resulting in immune tolerance or suppression that favors tumor survival and progression. The gene discussed is CD163; the disease is tongue squamous cell carcinoma.