When evaluating the activity of MPO (granular component of mononuclear lymphocytes considered an antibacterial enzyme), there is an increase in the values of each group that received ligation-induced periodontitis, mainly in groups P20 and P40, infiltrate Neutrophils promotes the destruction of the periodontium with the release of enzymes and reactive oxygen species (ROS).25 Periodontal inflammation is not limited to local oral sites and reflects systemic abnormalities due to the release of inflammatory mediators and ROS in the blood.26 The gene discussed is MPO; the disease is periodontitis.