Collectively, matrix degradation can effectively promote the deep penetration of nanoparticles, remodel matrix mechanics, regulate macrophage polarization, and blocking the activation of the STING pathway in macrophages can effectively reverse the activation of HSCs and further remodel the matrix mechanics, thus achieving the ECM-cell-ECM closed-loop reversal of liver fibrosis. This evidence concerns the gene STING1 and Hepatic fibrosis.