Indicators related to iron metabolism (transferrin,ferritin, and transferrin receptor) have the potential to directly or indirectlyimpact the onset and progression of DM (19).In a study on DOP using rats, Wang et al. (20) found that treatment of osteoblasts with HG decreased GPX4 expression,increased ROS levels, and led to the accumulation of lipid peroxides. The gene discussed is TFRC; the disease is diabetes mellitus.