GPX4 and diabetes mellitus: Indicators related to iron metabolism (transferrin,ferritin, and transferrin receptor) have the potential to directly or indirectlyimpact the onset and progression of DM (19).In a study on DOP using rats, Wang et al. (20) found that treatment of osteoblasts with HG decreased GPX4 expression,increased ROS levels, and led to the accumulation of lipid peroxides.