OPRM1 and dengue disease: Furthermore, several ARGs demonstrated high abundance in a subset of patients (shown by distinct clustering in the heatmaps) while being less prevalent in others (acrB, AAC(6’)-lb7, sul1, OPrM, MexJ, aadA24 in COVID-19 and sul1, TEM-230, aadA8b, CTX-M-77 in dengue), highlighting inter-patient variability in the resistome profiles (Fig 2d.i and 2d.ii).