Finally, the intersection of the genes from five algorithms is shown in the Venn diagram (Fig 6G) for analysis, and the intersected genes were the hub genes for sepsis, comprising nine hub genes: MPO, ELANE, PRTN3, CTSG, MMP9, CAMP, ITGAM, CXCR2, and FCGR3B. The gene discussed is CXCR2; the disease is Sepsis.