CACNA1C and Brugada syndrome: In that study, after screening 82 probands with Brugada syndrome, gene mutations to the α1 (A39V and G490R to CACNA1C; SQT-4) and β2b (S481L to CACNB2b; SQT-5) subunits of L-type calcium channels were identified in the probands exhibiting short QTc intervals [5].