The SIRT1 protein levelwas the highest in the ascending aortic aneurysm group (214, interquartilerange [IQR] 79 - 270), followed by the dissection group (172, IQR 148 -224), and the lowest in the control group (104, IQR 78 - 123) (P = 0.014).SIRT1 level was found to be low in patients with coronary artery disease (P= 0.001), peripheral artery disease (P = 0.008), and hypertension (P =0.023). The gene discussed is SIRT1; the disease is peripheral arterial disease.