Sirtuins are categorized into seven subtypes, with SIRT1, SIRT6, and SIRT7located in the nucleus, SIRT3, SIRT4, and SIRT5 in the mitochondria, and SIRT2functioning in the cytosol[1].Sirtuin 1 (SIRT1), the most extensively studied sirtuin, plays various roles in cellaging, metabolism regulation, deoxyribonucleic acid (DNA) repair, cardiovascularprotection, inflammation, apoptosis, and autophagy[2] Several studies have established its associationwith diabetes, demonstrating increased glucose tolerance and insulin secretion uponSIRT1 overexpression[3]. Here, SIRT1 is linked to diabetes mellitus.