Studies using human tissues, such as the internal mammary artery, aorta, and carotidendarterectomy samples, have demonstrated the presence of SIRT1, which plays a rolein preventing DNA damage and may have a protective effect against atherosclerosis.However, the study mentioned that suggests SIRT1's potential regression of medialdegeneration was based on mouse experiments, not human tissue[21]. The gene discussed is SIRT1; the disease is atherosclerosis.