CREB1 and melanoma: These data show that the GCP‐2 CREB activation axis profoundly contributes to the melanoma‐promoting “glycolytic state” (also referred to as “Warburg‐like effect”), while suppressing the “oxidative state.” These data, in addition, provide strong evidence for the impact of peritumoral senescent fibroblasts driving melanoma progression and clearly uncover CREB activation as a major switch for metabolic transformation towards neoplastic progression.