A375 melanoma cells were stained green, indicative of melanoma‐specific Melan A. The lack of GCP‐2 staining in connective tissue streaks between melanoma cells contrasted with marked GCP‐2 staining (red) in explanted melanomas derived from the injection of non‐silenced replicative senescent fibroblasts (GCP‐2 WT) together with A375 melanoma cells (Figure 3D, left panel). Here, MLANA is linked to melanoma.