CREB1 and cancer: CREB activation has been reported to be associated with a variety of human cancers (Chhabra et al. 2007; Crans‐Vargas et al. 2002; Seo et al. 2008), and a CREB regulon has previously been studied in the PC12 neuroblastic cell line (Impey et al. 2004), without functional analyses of CREB target genes in the context of metabolic reprogramming or tumor progression.