Based on an initial in vitro screen of SASP components, we here identified the chemokines granulocyte chemotactic protein‐2 (GCP‐2/CXCL6) and epithelial‐derived neutrophil attractant‐78 (ENA‐78/CXCL5), physiologically involved in neutrophil attraction to sites of tissue infection, to be upregulated in the skin of healthy old individuals and old but not young melanoma patients. Here, CXCL5 is linked to melanoma.