CREB1 and melanoma: Interestingly, apart from melanoma suppression, overexpression of the studied combinations of TCA enhancing enzymes (PDH‐PDP‐GDH) or the employment of a CREB inhibitor (CREBi) led to an almost complete restoration of the phospho‐protein pattern of activated TCA enzymes (data not shown), increased TCA metabolites, and resulted in a profound suppression of glycolysis (data not shown), demonstrating that fueling of the TCA cycle and not the toxicity of accumulating substrates are responsible for our observations.