GzmA expression is also positively associated with increased infiltration of dendritic and CD8+ T cells, suggesting its cytotoxic function in antitumor immunity.[3] Paradoxically, extracellular GzmA has been implicated in promoting colorectal cancer through macrophage‐mediated release of interleukin (IL)‐6, a proinflammatory cytokine that activates STAT3‐driven tumorigenesis.[4] These multifaceted roles underscore the need for selective tools to detect and study GzmA in a cell and context‐specific manner with high spatiotemporal resolution. This evidence concerns the gene GZMA and colorectal cancer.