GZMA and neoplasm: Perforin polymerizes to form transmembrane pores in the target cell, facilitating Gzm entry into the cytosol and initiating cell death through diverse mechanisms.[1] Granzyme A (GzmA), the most abundant granzyme in humans, has been shown to induce caspase‐independent cell death resembling apoptosis,[1] though pyroptosis may also occur in cells expressing gasdermin B.[2] In breast cancer, elevated levels of GzmA within the tumor immune microenvironment (TIME) correlate with improved disease‐specific survival and progression‐free interval.