To further evaluate the role of CXCR3 and CCL5 in the course of chronic hepatitis B and their potential for future treatment, we analyzed single-cell RNA sequencing data from the public database GSE247322, examining the expression of CXCR3 and CCL5 in PBMCs of CHB patients with high viral load. The gene discussed is CCL5; the disease is chronic hepatitis B virus infection.