In the MGS group, the percentage of CD11b+/CD27− terminally differentiated, cytolytic NK cells progressively increased on days 3 and 7 across all tissues examined, including WB, BM, LNs, spleen, and liver (all P < 0.001), suggesting active maturation toward cytolytic phenotypes in the context of moderate sepsis. The gene discussed is ITGAM; the disease is Mungan syndrome.