Conversely, immature, cytokine-producing CD11b−/CD27+ NK cells progressively declined in the MGS group (all P < 0.001), whereas their sustained presence or increase in the HGS group indicates that HGS may hinder NK cell maturation and promote the accumulation of immature subsets (Table 3 and Fig. S3). The gene discussed is ITGAM; the disease is Mungan syndrome.