GZMB and Sepsis: Together with these coherent data from diverse examinations, early alterations in GzmB production and cytotoxicity against infected cells reflect dynamic shifts in overall NKA that vary with sepsis lethality, as follows [13, 27, 57]: (1) NKA is transiently suppressed after sepsis with lower predicted short-term mortality but gradually recovers; (2) in fatal cases, NKA remains persistently impaired; and (3) restored NKA in milder cases does not provoke hypercytokinemia.