Recent findings suggest that clozapine’s improvements in sensorimotor gating, an endophenotype of schizophrenia characterized by deficits in information processing, depend on the modulation of p11, which regulates mGluR5 synaptic clustering [153] and has also been implicated in antidepressant effects and suicide risk reduction [154], potentially explaining the observed efficacy of clozapine in reducing suicide risk [155]. The gene discussed is GRM5; the disease is schizophrenia.