Similarly, upregulation of TRPV1 inhibited adipogenesis in 3T3-L1 preadipocytes, and obesity was prevented in mice treated with fid TRPV1 agonists for 120 days compared with TRPV1-knockout mice (Zhang et al. 2007). Here, TRPV1 is linked to obesity due to melanocortin 4 receptor deficiency.