Considering that we found ANPEP, another peptidase known to correspondingly modulate CXCL11 signaling70, to be downregulated in the aggressive disease patient group, puts the proposed CXCL11-DDP4 interaction into an interesting perspective strongly suggesting further studies on the role of peptidase-based alteration of chemokine signaling in PCa. This evidence concerns the gene CXCL11 and posterior cortical atrophy.