The microglial transcriptome analysis showed that the induction of proinflammatory cytokines and chemokines and the downregulation of microglial-mobility- and phagocytosis-associated genes in excessively activated microglia of the synucleinopathy mouse model while these were rescued by NFAT1 inhibition (Fig. 4). Here, NFATC2 is linked to synucleinopathy.