This is an NFκB-independent pathway—therefore, the inhibition of the downstream elements of this cascade may reduce the off-target effects of TLR2 inhibition in synucleinopathies and selectively reduce microglial neurotoxic inflammation while avoiding the inhibition of NFκB-dependent pathways that may play central roles in microglial neurohomeostasis83,84. This evidence concerns the gene NFKB1 and synucleinopathy.