Our study observed an increase in the interaction between FGF23 or FGF3 and FGFR1 receptor-ligands between MCs and VCAN-expressing CAFs, suggesting a mechanism by which MCs secrete fibroblast growth factors that enhance the activation of VCAN-expressing CAFs, thereby influencing the TME in Fibrosis+ LM. Here, FGF3 is linked to fibrosis.