The consistent pattern of reduced PC differentiation observed both in vitro and in living organisms, immunoglobins, anti-dsDNA antibody titles, proteinuria and glomerular deposition of immune complex in Ythdf1-deficient mice substantiates its significance in the development of SLE and suggests its potential as a promising target for SLE treatment. Here, YTHDF1 is linked to systemic lupus erythematosus.