We found that reduced FHL2 (four and a half LIM domains protein 2, an adapter and modifier in protein interactions), elevated YAP1 (Yes-associated protein 1, a core transcriptional co-activator in the Hippo pathway regulating organ size and tissue regeneration) and increased sFRP2 (secreted frizzled-related protein 2, an extracellular secreted protein) are closely associated with pathological vascular remodeling in tendinopathy. Here, YAP1 is linked to disease of the tendon.