Shared genes downregulated in males and upregulated in females included primary neurodevelopment-associated genes, such as the synaptic organizer (Cbln) (whose impairment causes social deficits) [39], synaptic scaffolding protein Cttnbp2 (whose deficiency causes autism-like behavior) [40], and synaptic vesicle protein Sv2a (with its reduction observed in schizophrenia) [41]. This evidence concerns the gene CTTNBP2 and schizophrenia.