Studies have demonstrated that Clec5a is involved in the formation of neutrophil extracellular traps and the regulation of IRs during P. aeruginosa infection and that Clec5a blocking can alleviate bacterium-induced lung injury17; however, it has not been reported in otitis media, which is mainly infected by P. aeruginosa. The gene discussed is CLEC5A; the disease is otitis media.