Hypoalbuminemia may decrease oncotic pressure and intravascular volume (Sganzerla et al. 2025; Sicova et al. 2024; van de Wouw and Joles 2022), while elevated CRP levels reflect chronic systemic inflammation, which may affect vascular reactivity and endothelial function (Wachtendorf et al. 2022; Wang et al. 2024; Widlansky 2003). The gene discussed is CRP; the disease is inflammatory response.