The TME is characterized by a complex network of suppressive immune cells, such as tumor-associated macrophages (TAMs), regulatory T cells (Tregs), and myeloid-derived suppressor cells (MDSCs), which creates a hostile environment for CAR-T cells and secretes immunosuppressive factors such as transforming growth factor-beta (TGF-β) and interleukin-10 (IL-10) [3, 4]. The gene discussed is IL10; the disease is neoplasm.