Wu et al. [30] reported that administration of live A. muciniphila (5 × 109 CFU/200 μL) for eight weeks improved the expression of tight junction proteins (ZO-1, Occludin, Claudin-1/4) and reduced LPS flux in mice with metabolic dysfunction-associated fatty liver disease (MAFLD)-hepatocellular carcinoma (HCC) fed high-fat, high-cholesterol (HFHC) and methionine-choline-deficient (MCD) diets. This evidence concerns the gene TJP1 and fatty liver disease.