Additionally, increased expression of B-cell activating factor (BAFF) and C-X-C Motif Chemokine Ligand 13 (CXCL13) within COPD lung tissue has been shown to sustain B-cell survival and follicle formation, reinforcing the autoimmunity loop [9,30]. The gene discussed is CXCL13; the disease is chronic obstructive pulmonary disease.