Recent findings underscore the pivotal role of key cytokines and chemokines – such as IL-17, TNF-α, IL-6, BAFF, and CXCL13 – as well as specific autoantibodies (e.g. ACPA, ANA) that not only drive local inflammation but may also perpetuate systemic autoimmunity in susceptible individuals. Here, IL17A is linked to Autoimmunity.