Although pre‐dysfunctional cells are characterized by high expression of Granzyme K (GZMK), low expression of Granzyme B (GZMB) and intermediate expression of markers, such as Programmed cell death 1 (PDCD1) and Lymphocyte activation gene 3 (LAG3),44, 45, 46, 47 reanalysis of NSCLC scRNA‐seq data (GSE99254) revealed that the CXCR4high CD8+ T cell population exhibited GZMKhigh and GZMBlow expression, suggesting that these cells represent pre‐dysfunctional CD8+ T cells (Figure S6). This evidence concerns the gene PDCD1 and non-small cell lung carcinoma.