The AMPK/ACC pathway is a key influencer of adipogenesis, the Akt/GSK-3β pathway is a key influencer of glycogen synthesis, the VEGF/KDR pathway ameliorates caveolae-mediated hyperpermeability induced by high glucose, and the endothelial hyperpermeability induced by hyperglycemia is an important prerequisite for the development of AS. This evidence concerns the gene GSK3B and Hyperglycemia.